Semaglutide works as a GLP-1, or glucagon-like receptor-1, agonist. It mimics the action of a naturally occurring hormone in the body called GLP-1. By doing so, semaglutide works to increase insulin secretion from the pancreas in response to eating, lowering blood sugar levels to help reduce cravings. It also works on the region of the brain involved in appetite regulation, by signalling a feeling of fullness and reducing appetite. Semaglutide also slows down the rate at which food leaves your stomach, helping you to feel fuller for longer.

Tirzepatide (Zepbound brand) is used for weight loss, to help lose weight and keep weight off. Tirzepatide works for weight loss by decreasing appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time. Tirzepatide is a once-weekly injection given under the skin.